Introduction
Classification of peptides in SwePep
Current status of SwePep
Updates
Submissions of peptides
Introduction
SwePep is an endogenous peptide database developed by the Laboratory for Biological and Medical Mass Spectrometry at Uppsala University to aid mass spectrometric identifications. At this stage the information in SwePep is biased to the species handled by the developers, ie. rat, and mouse. It is anticipated that the information in SwePep will increase with extended use and joint submission.
Classification of peptides in SwePep
  • Biological active peptides. This group of peptides contains the classical neuropeptides, such as substance P, neurotensin, enkephalins, dynorphins, that are present in a neuron together with classical neurotransmitters. This group also contains peptides functioning as hormones, a class of peptides that are secreted into the blood stream to exert endocrine functions. All the neuropeptides and hormones in this group have known biological functions.

  • Potential biological active peptides. This group contains pharmacologically uncharacterized peptides (between 3 and 100 amino acids) that potentially are biologically active. They are identified in tissues or body fluids, which has instantly been proteolytically deactivated post mortem or post sampling, and have similar characteristics as the neuropeptides and hormones, i.e., they have specific convertase processing sites 16. Modifications such as amidation of the C-terminal and N-terminal acetylation are regarded as important criteria, since many bioactive peptides are amidated by conversion of a C-terminal glycine to a carboxamide.

  • Uncharacterized peptides. Peptides that not fulfill the criteria of the groups above belong to this group. Among others, this group consists of peptides from samples not rapidly proteolytically deactivated post sampling.
Current status of SwePep
SwePep was last updated 2006-02-15 with the UniProt release 49.0 February 2006.
There are 4180 unique peptides in SwePep.

  Biological active peptidesPotential biological active peptidesUncharacterized peptides
UniProt413600
Exprimentally identified peptides372816

Updates
The data from UniProt will be updated every time a major release of UniProt is made. The rest of the data will be updated continuously.
Submission of peptides
We wholeheartedly encourage external submission of novel peptides to our database. In order to submit your peptides the following procedure is suggested. Send an e-mail, containing the peptide sequences, brief description of the experiment in which they were detected, their MS/MS spectra (preferably in numerical format) and/or references to publications where these peptides were published.